Priority 4:

Providing Targeted Funding for the Development of New Tools

Research leveraging innovative technologies, such as AI and large-scale data analysis, has historically been underfunded, particularly in neurodegeneration. Traditional funding models often prioritize more traditional methodologies over high-risk, high-reward approaches, leaving cutting-edge research without the necessary resources to thrive. As a result, promising advancements—such as AI-driven drug discovery, biomarker identification, and personalized treatment strategies—have been slow to reach their full potential.

Priority 4 will increase investment in these areas and equip the field with the computational resources needed to drive real-world progress.

Specifically, Priority 4 will incorporate the following programs:

Global Data Challenges to engage the solver community to tackle critical research questions—such as target identification, patient subgrouping, and early disease detection—in collaboration with existing data portals.

Computational Research Competitive Funding Program to support cutting-edge AI and data-driven projects that push the boundaries of neurodegeneration research.

Tools Repository to create a curated database of relevant, high-quality analytical tools, regularly updated and maintained, to help researchers analyze key data types and answer pressing scientific questions.

Venture Philanthropy Fund to develop an investment vehicle that will support cutting-edge technology-driven startups and innovations that are aligned with our philanthropic mission.

By fostering innovation, expanding computational resources, and providing sustained funding, these efforts will accelerate AI adoption in neurodegeneration research, driving faster discoveries and better patient outcomes.