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PATH-ND is creating an open, connected resource that researchers can use to ask new questions, develop new tools, and accelerate discovery.
From brain tissue to AI discovery.
Transforming neuropathology for the AI era.
Neuropathology has always been the ground truth for understanding the brain.
PATH-ND transforms it into an AI-ready scientific resource—curated, harmonized, standardized, and connected for discovery.
Every discovery starts with a brain
Donated brain tissue from individuals with and without neurodegenerative disease makes research possible.
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Understand disease
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Advance Treatments
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Improve lives
Tissue Slide Preparation
Tissue is processed, stained and digitized into high-quality slide images
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Fixation and processing
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Staining and sectioning
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High resolution imaging
Digitization turns slides into data
High-resolution images become data, ready for AI and cross disease research.
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Automated quality metrics
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Standardized & harmonized
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High resolution imaging
Data Quality Assurance
AI and expert review ensure accurate, consistent, high quality data
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Quality control and validation
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Expert pathologist review
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Reliable reproducable data
AI-Ready Datasets
Curated, standardized and linked with clinical data to power new discoveries
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Curated & harmonized
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Linked to clinical data
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Open for research & Innovation
Global Collaboration
Connecting researchers, institutions and data worldwide to accelerate progress
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Academic & industry partners
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Global brain banks
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Shared standards & tools
AI unlocks new insights
Turns complex data into answers and new understanding
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Find patterns & generate hypotheses
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Accelerate drug development
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Personalized approaches
Better Insights, Better Treatments
Our shared data and collaboration lead to a healthier future for patients
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More effective treatments
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Improved quality of life
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Greater impact
Digitization is only the beginning.
The goal isn’t simply to create digital images.
It’s about bringing together the people, processes, technologies, and data needed to turn brain tissue into a connected resource for discovery.
Multiple disease, one connected resource.
Neurodegenerative diseases don’t exist in isolation. They can share biological pathways, cellular changes, and mechanisms of disease.
Studying them together can reveal connections that studying them separately cannot.
10,000
Target brain cases
4,000+
cases and healthy controls
5 disease areas
and growing